Beijing has never fully co-operated with international investigators, impeding the search for a definitive answer. But scientists continue their quest to establish the causes of a global health crisis that killed millions of people, caused trillions of dollars of economic damage and increased fears over the risks of virus research.

The CIA now assesses the virus that causes Covid-19 more likely originated from an accidental lab leak in China, rather than occurring naturally, according to a statement from the agency Saturday, just days after Director John Ratcliffe took the reins.