Researchers have revealed new details about the CRISPR-Cas5-HNH/Cascade complex, a variant of the type I-E CRISPR-Cas system, ...
In a study published in Nature Structural and Molecular Biology, scientists from the Department of Medical Biochemistry and ...
Laboratory for Research on the Structure of Matter (LRSM), University of Pennsylvania, Philadelphia, United States ...
These results are consistent with a molecular mechanism by which microbes and or microbial-derived indoles, regulate functional changes in the BLA neurons. Moreover, this microbe metabolite regulation ...
Modulation of Protein–Protein Interactions with Molecular Glues in a Synthetic Condensate Platform
Attribution (BY): Credit must be given to the creator. Misregulation of protein–protein interactions (PPIs) underlies many diseases; hence, molecules that stabilize PPIs, known as molecular glues, are ...
In this important work, Lodhiya et al. provide evidence that excessive ATP underlies the killing of the model organism Mycobacterium smegmatis by two mechanistically-distinct antibiotics. The data are ...
The international team describes their results and the underlying molecular mechanism in Cell Metabolism. Ergothioneine is a natural compound found in certain fungi such as oyster or shiitake ...
2013). By offering these capabilities, POLYVIEW-3D plays a pivotal role in the optimization of mRNA-LNP vaccines. Its ability to model complex interactions at the molecular level, visualize the ...
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