CRISPR system variant shows a novel DNA cleavage mechanism
Researchers have revealed new details about the CRISPR-Cas5-HNH/Cascade complex, a variant of the type I-E CRISPR-Cas system, ...
Water molecules help proteins read the human genome, research reveals
In a study published in Nature Structural and Molecular Biology, scientists from the Department of Medical Biochemistry and ...
Nature16d
Structure of the Cell Nucleus
From the evidence of karyomeres in animal cells, the nucleus is regarded as a compound structure, and it was further suggested that the spindle is also compound, the real unit in mitosis being a ...
Frontiers25d
Brain network and energy imbalance in Parkinson’s disease: linking ATP reduction and α-synuclein pathology
Deficits in ATP production in PD can severely impair these hubs ... the axonal arbor in the striatum of a typical substantia nigra dopaminergic neuron displays a hyperbranched structure with a dense ...
C&EN29d
Discovery of Selenium-Containing Derivatives as Potent and Orally Bioavailable GLP-1R Agonists
Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China Department of Medicinal Chemistry, School ...